How to write a Clotrimazole and Age-Appropriate Teaching Plan (Solved)

How to write a Clotrimazole and Age-Appropriate Teaching Plan (Solved)

Therapeutic Actions of Clotrimazole

According to Neil, Khatter and Khan (2021), clotrimazole is an antifungal agent that exerts its action principally by destroying the cytoplasmic membrane of the fungus, impairing its permeability. In the process, it prevents ergosterol biosynthesis through a concentration-dependent mechanism by inhibiting 14-alpha lanosterol demethylation (Neil et al., 2021). Inhibition of ergosterol synthesis prevents the cell from building a strong and functional cell membrane. Additionally, ergosterol stimulates fungal cell growth; therefore, its inhibition results in a dose-dependent fungal growth inhibition. Other pharmacological actions apart from antimycotic functions associated with clotrimazole include depleting intracellular calcium, blocking voltage-dependent calcium channels and calcium-dependent potassium channels, and inhibiting sarcoplasmic reticulum calcium ion ATPase (Neil et al., 2021).

Antifungal Drugs Uses and Side Effects

According to Houšť, Spížek, and Havlíček (2020), different classes of antifungal drugs are available for treating various systemic illnesses. Each class targets a different part of the fungal cell. The first class is polyene, which includes amphotericin B. Amphotericin acts on ergosterol to exert fungicidal activity against candida, aspergillus fumigatus, and aspergillus flavus. The second class consists of first and second generation of triazoles. They also exert their action by inhibiting ergosterol biosynthesis during lanosterol demethylation. These actions have a fungistatic effect on yeasts and fungicidal on apergillus species. The third class consists of echinocandins which inhibit the synthesis of beta-D-glucans within the fungal cell wall. This action has a fungistatic effect on aspergillus species and fungicidal against candida. The last class is flucytocine (5-FC), a pyrimidine analogue, whose mechanism of action s on the fungus nucleus. It inhibits protein and deoxyribonucleic acid biosynthesis (Houšť et al., 2020).

The most common side effects of antifungal drugs are associated with their long-term use. These side effects include nephrotoxicity, pathogen resistance, hepatotoxicity, and myelotoxicity (McKeny, Nessel & Zito, 2021).

Teaching Plan

A six-week old child is at a high risk of candidiasis, especially when on antibiotics. Also, taking a long time between diaper changes significantly contributes to developing candidiasis. Poor hygiene is another factor. Educating Ms. Jones on the important aspects of the infection and its treatment is essential for the baby’s recovery and preventing disease recurrence. The objectives for Ms. Jones teaching plan include:

  • To understand the significance of adherence to the treatment regimen
  • To understand the preventive measures necessary to avoid infection recurrence
  • To understand when to seek medical help

Applying clotrimazole cream on the affected area for 14 days is vital for full recovery of the child and to ensure the pathogen does not develop drug resistance. Several simple preventive measures can ensure the child does not contract candidiasis again, and promote faster healing. These include, changing diapers often, and allowing the child some diaper-free time during the day, using antibiotics only when necessary, and assessing for signs of candidiasis after using antibiotics (Marianne & Stephen, 2022). Ms. Jones should seek medical help when the child’s symptoms worsen or new symptoms arise. Also, she should seek help when the child manifests signs of skin infection such as increased erythema, warmth, fluid accumulation or swelling (Marianne & Stephen, 2022). MS. Jones should then come for a follow-up appointment after the 14 days of therapy.


Houšť, J., Spížek, J., & Havlíček, V. (2020). Antifungal Drugs. Metabolites10(3), 106.

Khatter, N. J., & Khan, M. A. (2020). Clotrimazole. Retrieved from,the%20treatment%20of%20fungal%20infections

Marianne F. and Stephen M. (2022). Candidiasis in children. University of Rochester medical center. Retrieved from

McKeny, P. T., Nessel, T. A., & Zito, P. M. (2021). Antifungal antibiotics. In StatPearls [Internet]. StatPearls Publishing. Retrieved from

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