Response to Discussion (Shantel) 805
Hi, the discussion post on the process of atherosclerosis and ways to reduce the risk factors is well explained. I coincide that atherosclerosis is the thickening of the walls of blood vessels as a result of a buildup of lipid-rich macrophages and cholesterol. Calcium and cellular debris within the blood vessels’ intima may also lead to the building up of masses resulting in occlusion of the blood flow. To add to what you have partially explained, the pathophysiology of atherosclerosis is that hypercholesterolemia or hyperlipidemia triggers an increase in atherosclerosis (McCance, 2019). The rise in plasma cholesterol levels attributes to changes in arterial endothelial permeability that allow migration of lipids, more so the LDL particle, into the arterial wall. The progressive building up of lipid masses on the arterial reduces the blood volume to complete occlusion of the blood vessel.
I agree with the position that atherosclerosis results in a rise in cardiovascular disorder; the reduction of the blood volume reduces the cardiac output, thus causing cyanosis and other presentation of deprived blood circulation. In addition to the mentioned risk factors of atherosclerosis, such as dyslipidemia, hypertension, obesity, and inability to participate in physical exercises, genetic factors also contribute to atherosclerosis. The reduction ways to reduce atherosclerosis are enhanced in varied ways. Reduction of the associated triggers of atherosclerosis significantly helps in the removal of atherosclerosis. For example, you mentioned that losing weight among obese people reduces lipids, which triggers the formation of atherosclerosis. In addition to the mentioned ways to reduce the risk factors, pharmacologic therapy is also vital in lowering atherosclerosis, especially when the buildup of masses on the walls of the arteries is rigid. Antiplatelet, such as antithrombotic agents and statins, help reduce the lipid masses occluded in the wall of the arteries.
McCance, K., Huether, S. (2019). Pathophysiology: The biological basis for disease in adults and children. (8ed)Elsevier.
Riccardi, G., Giosue, A., Calabrese, I., Vaccaro, O. (2022). Dietary recommendations for the prevention of atherosclerosis. Cardiovascular Research, 118(5), 1188-1204. https://doi.org/10.1093/cvr/cvab173
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